For a long time the morphologic diagnosis of diseases of the pancreas - which is the most hidden organ of the abdomen - by means of radiologic methods was inade quate. Diagnostic radiology of pancreatic diseases has been revolutionized by new cross-sectional methods such as computed tomography with volume CT scanning, further progress in ultrasonography in the form of color duplex Doppler, and magnetic resonance imaging. Therefore we had the idea of publishing an up-to-date treatise on rad...

This book provides an up-to-date description of the biomimetic membrane technology that is essential for medical diagnostics and therapeutics. Fundamental and background information on the latest biomimetic membrane technology will be enhanced by descriptions of the medical diagnostic and therapeutic systems that include biomimetic membrane technology at the core of the systems. This is an ideal book for biomedical scientists, clinicians and scientists who design devices for medical techno...

This open-access textbook is an excellent introduction to systems biology, which has developed rapidly in recent years. It discusses the processes in living organisms in an integrated way, enabling the reader to understand the fundamental principles and cause-effect relationships in biology and biochemistry. The authors have chosen an original but at the same time clear way of presenting the topics, repeatedly drawing comparisons and models from the macroscopic world and making the reader ...

Peptide therapy has become a key strategy in innovative drug development, however, one of the potential barriers for the development of novel peptide drugs in the clinic is their deficiencies in clearly defined chemistry, manufacturing and controls (CMC) strategy from clinical development to commercialization. CMC can often become a rate-limiting step due to lack of knowledge and lack of a formal policy or guidelines on CMC for peptide-based drugs. Regulators use a risk-based approach, rev...

“… a must-read for all modern bio-scientists and engineers working in the field of biotechnology.” – Biotechnology Journal, 2012, 7A cutting-edge guide on the fundamentals, theory, and applications of biomechatronic design principlesBiomechatronic Design in Biotechnology presents a complete methodology of biomechatronics, an emerging variant of the mechatronics field that marries biology, electronics, and mechanics to create products where...

Advancements in cancer diagnosis and treatment have extended the lives of many patients facing numerous types of cancer over the years. Research on best practices, new drug development, early identification, and treatment continues to advance with the ultimate goal of uncovering a cure for cancer in all its forms. Oncology: Breakthroughs in Research and Practice features international perspectives on cancer identification, treatment, and management methodologies in addition to patient cons...

Mass Spectrometry for the Clinical Laboratory is an accessible guide to mass spectrometry and the development, validation, and implementation of the most common assays seen in clinical labs. It provides readers with practical examples for assay development, and experimental design for validation to meet CLIA requirements, appropriate interference testing, measuring, validation of ion suppression/matrix effects, and quality control. These tools offer guidance on what type of instrumentation...

This book describes the role modern pharmaceutical analysis plays in the development of new drugs. Detailed information is provided as to how the quality of drug products is assured from the point of discovery until the patient uses the drug. Coverage includes state-of-the-art topics such as analytics for combinatorial chemistry and high-throughput screening, formulation development, stability studies, international regulatory aspects and documentation, and future technologies that are lik...

Detailing formulation approaches by stage of discovery to early development, this book gives a “playbook” of practical and efficient strategies to formulate drug candidates with the least chance of failing in clinical development.• Comes from contributing authors with experience developing formulations on the frontlines of the pharmaceutical industry• Focuses on pre (or non-) clinical and early stage development, the phases where most compounds are used in drug research

Pharmaceutical Nanotechnology: Innovation and ProductionWith its focus on concrete methods and recent advances in applying nanotechnology to develop new drug therapies and medical diagnostics, this book provides an overall picture of the field, from the fundamentals of nanopharmacy with the characterisation and manufacturing methods to the role of nanoparticles and substances. Actual examples of utilization include drug development issues, translation to t...

In this comprehensive two-volume resource on the topic senior lead generation medicinal chemists present a coherent view of the current methods and strategies in industrial and academic lead generation. This is the first book to combine both standard and innovative approaches in comparable breadth and depth, including several recent successful lead generation case studies published here for the first time.Beginning with a general discussion of the underlying principles and strategie...

The first introductory book on the subject, this book will provide a complete grounding to this pioneering field for students and professionals across biomedical engineering, biology and medicine. It features a comprehensive overview of original work in this revolutionary field. Topics discussed include drug delivery, cell-material interaction and gene therapy, accompanied by real-world examples and over 100 illustrations. The book teaches readers how to design and test their own nanomedic...