The study of gambling disorder is important from both clinical and research perspectives. Gambling disorder is a common disorder that is associated with significant morbidity (decreased self-esteem, comorbid substance use disorders, financial and legal difficulties, stress on relationships and families, and suicidality). Over the past 16 years, our understanding of the phenomenology, epidemiology, neurobiology, psychology, and treatment of this disorder has increased. Unfortunately, althou...

Bupropion holds a unique place due to its different pharmacological mechanism—dopamine and norepinephrine reuptake inhibition—with an overall mild but consistent activating effect. Bupropion is often used off-label by sleep specialists to reduce excessive daytime sleepiness and can result in difficulty with sleep onset if it is taken later in the day. This unique mechanism of action is shared with a newer agent, solriamfetol, which has been approved for the indication of excessive daytime ...