In The Case and Cure of a Deserted Soul, Joseph Symonds (d.1652) explores the nature, causes, and treatment of spiritual depression—a state that arises when God seems to hide his face, leaving the Christian to walk alone in a “dark night of the soul.” Every aspect of this condition is examined with a surgeon’s precision, a philosopher’s insight, and the Word of God’s wisdom on how to gain a firmer footing and emerge from this melancholy hour with renewed strength and vivacity....

SCN2A encodes a voltage-gated sodium channel (designated NaV1.2) vital for generating neuronal action potentials. Pathogenic SCN2A variants are associated with a diverse array of neurodevelopmental disorders featuring neonatal or infantile onset epilepsy, developmental delay, autism, intellectual disability and movement disorders. SCN2A is a high confidence risk gene for autism spectrum disorder and a commonly discovered cause of neonatal onset epilepsy. This remarkable clinical heterogene...

"Riveting. . . . A thoughtful biography." —New York Times Book ReviewGeneral Joseph E. Johnston was in command of Confederate forces at the South's first victory—Manassas in July 1861—and at its last—Bentonville in April 1965. Many of his contemporaries considered him the greatest southern field commander of the war; others ranked him second only to Robert E. Lee.But Johnston was an enigmatic man. His battlefield victories were never decisive. He f...

Long overshadowed by the American Civil War, the Mexican-American War (1846–1848) has received significantly less attention from historians partly because of its questionable origin and controversial outcome. Rather than treat the conflict with a form of historical amnesia, the contributors to this volume argue that the Mexican-American War was a formative experience for the more than three hundred future Civil War generals who served in it as lower-grade officers. The Mexican War was the ...

However, exciting new developments are on the verge of changing the treatment of this debilitating disorder. Two anabolic agents, the parathyroid hormone (PTH) and the fluoride ion, show tremendous promise as tools for building and retaining bone - with no adverse side effects. Anabolic Treatments for Osteoporosis is a comprehensive account of the latest studies that have been carried out on these two agents, and a thorough assessment of their prospects as osteoporosis therapeutics. This u...