This issue is the third issue Dr. John Calamia and colleagues have edited on cosmetic dentistry. This issue, titled "Modern Concepts in Aesthetic Dentistry & Multi-disciplined Reconstructive Grand Rounds," features 20 articles on Smile design, Proportional smile design, Use of Kois analyzer in the restoration of anterior dentition, Cements and adhesives for all-ceramic restorations, Replacement of old PFM crowns with all ceramic restorations, Cosmetic makeover insuring patient input, Ortho...

This issue of Heart Failure Clinics, devoted to Interventional and Device Therapy in Heart Failure, is edited by Deepak L. Bhatt and Michael R. Gold. Topics include The Role of Implantable Hemodynamic Monitors to Manage Heart Failure; Non-hemodynamic Parameters from Implantable Devices for Heart Failure Risk Stratification; Role of Percutaneous Revascularization in Patients to Improve Left Ventricular Function; Hemodynamic Support with Percutaneous Devices in Patients with Heart Failure; T...

This issue of Dental Clinics, edited by Lisa A. Thompson and Leonard J. Brennan, focuses on Geriatric Dentistry. Articles include: Our Current Geriatric Population: Demographic and Oral Health Care Utilization; Physiology of Aging of Older Adults: Systemic and Oral Health Considerations; Treatment Planning Considerations in Older Adults; Oral Health Disparity in Older Adults: Dental Decay and Tooth Loss; Oral Health Disparities in Older Adults: Oral bacteria, Inflammation and Aspiration Pn...

ICH - Safety Guidelines S1A – S9  S1A Guideline on the Need for Carcinogenicity Studies  S1B Testing for Carcinogenicity of Pharmaceuticals  S1C(R2) Dose Selection for Carcinogenicity Studies of Pharmaceuticals  S2(R1) Guidance on Genotoxicity Testing and Data Interpretation for Pharmaceuticals Intended for Human Use  S3A Note for Guidance on Toxicokinetics: The Assessment of Systemic Exposure in Toxi...

The orthodontic literature includes many articles on basic science and engineering research techniques, but clinicians are typically unfamiliar with the principles underlying these techniques and may also lack the background knowledge required for a full appreciation of their role. This book comprehensively reviews a wide array of the research methods most frequently encountered in the literature, encompassing the areas of materials science and clinical and biological research. The various...