This new edition offers a clear and through examination of the most recent results of thirty years of research on calcium-activated-neutral protease (CANP or Calpain). Coverage includes the implications of the recently gained ability to produce functionally active recombinant calpain in various human disorders such as cerebal ischemia, traumatic brain and spinal cord injury, cataract formation, myocardial infarction, and Alzheimer's disease. The resulting research to find more selective ca...

Perth Amboy, New Jersey, has undergone significant changes since it was settled by Europeans in 1651. It is a constantly evolving community, as seen in its famous waterfront, architecture, and industries that have developed throughout the years.

The 4th Industrial Revolution is here, and it is the catalyst of our mindset changes as we are facing a new world of digital transformation. Mindset stands for our outlook, attitudes, and behaviors toward the world. Now that the world is rapidly changing due to technological advances, our mindset needs to leap with the trend and enable us to excel in the new digital era.Many books may have touched on the subject of digital mindset but this book takes it to a new level. The new Cogn...

There is no other time in life when the provision of adequate and balanced nutrition is of greater importance than during infancy and childhood. During this dynamic phase characterized by rapid growth, development and developmental plasticity, a sufficient amount and appropriate composition of nutrients both in health and disease are of key importance for growth, functional outcomes such as cognition and immune response, and the metabolic programming of long-term health and well-being. Thi...

Advances in wide bandgap semiconductor materials are enabling the development of a new generation of power semiconductor devices that far exceed the performance of silicon-based devices. These technologies offer potential breakthrough performance for a wide range of applications, including high-power and RF electronics, deep-UV optoelectronics, quantum information and extreme-environment applications.This reference text provides comprehensive coverage of the challenges and latest r...

This book is contemporary, topical and global in its approach, and provides an essential, comprehensive treatise on bovine tuberculosis and the bacterium that causes it, Mycobacterium bovis. Bovine tuberculosis remains a major cause of economic loss in cattle industries worldwide, exacerbated in some countries by the presence of a substantial wildlife reservoir. It is a major zoonosis, causing human infection through consumption of unpasteurised milk or by close contact with infected anima...

Most of the antibiotics now in use have been discovered more or less by chance, and their mechanisms of action have only been elucidated after their discovery. To meet the medical need for next-generation antibiotics, a more rational approach to antibiotic development is clearly needed.Opening with a general introduction about antimicrobial drugs, their targets and the problem of antibiotic resistance, this reference systematically covers currently known antibiotic classes, their m...

A solid introduction to the practices, plans, and skills required for developing a smart system architectureInformation architecture combines IT skills with business skills in order to align the IT structure of an organization with the mission, goals, and objectives of its business. This friendly introduction to IT architecture walks you through the myriad issues and complex decisions that many organizations face when setting up IT systems to work in sync with busi...

This book provides an easy insight into the essentials of cybersecurity, even if you have a non-technical background. You may be a business person keen to understand this important subject area or an information security specialist looking to update your knowledge.‘The world has changed more in the past 10 years than in any 10 year period in human history... Technology is no longer a peripheral servant, it shapes our daily lives. Companies that can use technology wisely and well ar...

This book is an overview of the strategies to generate high-quality films of one-dimensional semiconductor nanostructures on flexible substrates (e.g., plastics) and the use of them as building blocks to fabricating flexible devices (including electronics, optoelectronics, sensors, power systems). In addition to engineering aspects, the physics and chemistry behind the fabrication and device operation will also be discussed as well. Internationally recognized scientists from academia, nati...

The microenvironment in which a tumor originates plays a critical role in its initiation and progression. Tumor Microenvironment reviews the importance of tumor microenvironment in cancer management. Particular emphasis is placed on discussing how the unique characteristics of the tumor microenvironment not only impact disease progression and response to conventional anticancer therapies, but have also led to the identification of potential new therapeutic targets and treatment po...

We're at an inflection point in data, where our data management solutions no longer match the complexity of organizations, the proliferation of data sources, and the scope of our aspirations to get value from data with AI and analytics. In this practical book, author Zhamak Dehghani introduces data mesh, a decentralized sociotechnical paradigm drawn from modern distributed architecture that provides a new approach to sourcing, sharing, accessing, and managing analytical data at scale....