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Genotoxicity Assessment

Methods and Protocols

Redigeret af Alok Dhawan, Mahima Bajpayee ...

Serier serie Springer Protocols
This third edition volume explores the latest advancements in genotoxicity testing and combines established assays with emerging technologies. Organized into five thematic sections, the book examines gene mutation assays, assays for chromosomal abnormalities, tests for primary DNA damage, assays in alternatives to animal models, as well as multipronged approaches to the assessment of genotoxicity. ... Læs mere

1.344,86 kr.

This third edition volume explores the latest advancements in genotoxicity testing and combines established assays with emerging technologies. Organized into five thematic sections, the book examines gene mutation assays, assays for chromosomal abnormalities, tests for primary DNA damage, assays in alternatives to animal models, as well as multipronged approaches to the assessment of genotoxicity.
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The AGT Cytogenetics Laboratory Manual

Redigeret af Marilyn S. Arsham, Margaret J. Barch, Helen J. Lawce ...

Cytogenetics is the study of chromosome morphology, structure, pathology, function, and behavior. The field has evolved to embrace molecular cytogenetic changes, now termed cytogenomics.Cytogeneticists utilize an assortment of procedures to investigate the full complement of chromosomes and/or a targeted region within a specific chromosome in metaphase or interphase. Tools include routine analysis ... Læs mere

1.471,24 kr.

Cytogenetics is the study of chromosome morphology, structure, pathology, function, and behavior. The field has evolved to embrace molecular cytogenetic changes, now termed cytogenomics.Cytogeneticists utilize an assortment of procedures to investigate the full complement of chromosomes and/or a targeted region within a specific chromosome in metaphase or interphase. Tools include routine analysis
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In Vitro Bioassay Techniques for Anticancer Drug Discovery and Development

af Dhanya Sunil, Raghu Chandrashekhar H, Pooja Kamath ...

This comprehensive and useful handbook represents a definitive up-to-date compendium of key in vitro bioassay methods that are employed to quantify and validate the anticancer activity of a drug candidate before it makes its way in to animal or clinical trials.In Vitro Bioassay Techniques for Anticancer Drug Discovery and Development covers the screening and evaluation of potential drug candidates ... Læs mere

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This comprehensive and useful handbook represents a definitive up-to-date compendium of key in vitro bioassay methods that are employed to quantify and validate the anticancer activity of a drug candidate before it makes its way in to animal or clinical trials.In Vitro Bioassay Techniques for Anticancer Drug Discovery and Development covers the screening and evaluation of potential drug candidates
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Biopharmaceutical Production Technology

Redigeret af Ganapathy Subramanian ...

Cost-effective manufacturing of biopharmaceutical products is rapidly gaining in importance, while healthcare systems across the globe are looking to contain costs and improve efficiency. To adapt to these changes, industries need to review and streamline their manufacturing processes.This two volume handbook systematically addresses the key steps and challenges in the production process and ... Læs mere

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Cost-effective manufacturing of biopharmaceutical products is rapidly gaining in importance, while healthcare systems across the globe are looking to contain costs and improve efficiency. To adapt to these changes, industries need to review and streamline their manufacturing processes.This two volume handbook systematically addresses the key steps and challenges in the production process and
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Drosophila

Methods and Protocols

Redigeret af Christian Dahmann ...

Serier serie Springer Protocols
This third edition expands on the previous editions by providing updated protocols and current methods that cover recent breakthroughs in Drosophila research. Chapters guide readers through FlyBase, versatile gene expression systems, analysis of microRNA function, single-cell transcriptome data and metabolism, recent applications of CRISPR for precise genome editing, transcriptional activation and ... Læs mere

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This third edition expands on the previous editions by providing updated protocols and current methods that cover recent breakthroughs in Drosophila research. Chapters guide readers through FlyBase, versatile gene expression systems, analysis of microRNA function, single-cell transcriptome data and metabolism, recent applications of CRISPR for precise genome editing, transcriptional activation and
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Fluorescence In Situ Hybridization (FISH)

Application Guide

Redigeret af Thomas Liehr ...

Serier serie Springer Protocols
This third edition provides protocols on fluorescence in situ hybridization (FISH) and comparative genomic hybridization approaches. Chapters provide new and updated methods on probe, cell types, tissues, organisms, plants, microorganisms, multicolor FISH procedures, chromosomes, breakpoints, cryptic aberrations, nuclear architecture, epigenetic changes, and comparative genomic hybridization ... Læs mere

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This third edition provides protocols on fluorescence in situ hybridization (FISH) and comparative genomic hybridization approaches. Chapters provide new and updated methods on probe, cell types, tissues, organisms, plants, microorganisms, multicolor FISH procedures, chromosomes, breakpoints, cryptic aberrations, nuclear architecture, epigenetic changes, and comparative genomic hybridization
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Chromosome Analysis

Methods and Protocols

Redigeret af Eisuke Gotoh ...

Serier serie Springer Protocols
This volume provides essential and fundamental protocols on manipulation chromosome. Chapters details methods on the preparation of mitotic chromosome, chromosome aberration, micronucleus (MN), comet assay, karyotyping, Fluorescent in situ hybridization (FISH), premature chromosome condensation (PCC), immunohistochemistry (IHC) staining, new generation sequencing technology and new chromosome ... Læs mere

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This volume provides essential and fundamental protocols on manipulation chromosome. Chapters details methods on the preparation of mitotic chromosome, chromosome aberration, micronucleus (MN), comet assay, karyotyping, Fluorescent in situ hybridization (FISH), premature chromosome condensation (PCC), immunohistochemistry (IHC) staining, new generation sequencing technology and new chromosome
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This volume explores the latest advancements and methodologies in studying Hox genes; gene regulation; and Hox gene expression, function, and regulation in various model organisms. The chapters in this book cover topics such as high-resolution imaging and gene editing, bioinformatics approaches ad chromatin analysis, Spatial technology (Curio), ChIP-Seq, and ATAC-Seq. There are also chapters on ... Læs mere

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This volume explores the latest advancements and methodologies in studying Hox genes; gene regulation; and Hox gene expression, function, and regulation in various model organisms. The chapters in this book cover topics such as high-resolution imaging and gene editing, bioinformatics approaches ad chromatin analysis, Spatial technology (Curio), ChIP-Seq, and ATAC-Seq. There are also chapters on
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Microarrays play an increasingly significant role in drug discovery. The commercial landscape has changed dramatically over the past few years and researchers have made great advancements with regard to construction and use. Now in its second edition, Applying Genomic and Proteomic Microarray Technology in Drug Discovery highlights, describes, and ... Læs mere

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Molecular Biomethods Handbook

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Serier serie Springer Protocols Handbooks
Recent advances in the biosciences have led to a range of powerful new technologies, particularly nucleic acid, protein and cell-based methodologies. The most recent insights have come to affect how scientists investigate and define cellular processes at the molecular level. Molecular Biomethods Handbook, 2nd Edition expands upon the techniques included in the first edition, providing theory, ... Læs mere

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Recent advances in the biosciences have led to a range of powerful new technologies, particularly nucleic acid, protein and cell-based methodologies. The most recent insights have come to affect how scientists investigate and define cellular processes at the molecular level. Molecular Biomethods Handbook, 2nd Edition expands upon the techniques included in the first edition, providing theory,
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This detailed volume explores the frontiers of this new era in cancer cytogenetics and cytogenomics, focusing on establishing a karyotype as an information-based genomic framework, as well as presenting technological platforms for collecting and analyzing data at the genome level. It begins with several conceptual chapters that introduce ideas such as the Genome Architecture Theory, forcefully ... Læs mere

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This detailed volume explores the frontiers of this new era in cancer cytogenetics and cytogenomics, focusing on establishing a karyotype as an information-based genomic framework, as well as presenting technological platforms for collecting and analyzing data at the genome level. It begins with several conceptual chapters that introduce ideas such as the Genome Architecture Theory, forcefully
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This fully updated volume assembles a comprehensive collection of methods, techniques, and strategies to investigate the molecular and cellular biology of peroxisomes in different organisms. Peroxisome research is on the rise, as novel functions and proteins of this dynamic organelle are still being discovered through studies in model systems including humans, mice, flies, plants, fungi, and yeast ... Læs mere

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This fully updated volume assembles a comprehensive collection of methods, techniques, and strategies to investigate the molecular and cellular biology of peroxisomes in different organisms. Peroxisome research is on the rise, as novel functions and proteins of this dynamic organelle are still being discovered through studies in model systems including humans, mice, flies, plants, fungi, and yeast
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The AGT Cytogenetics Laboratory Manual

In Vitro Bioassay Techniques for Anticancer Drug Discovery and Development

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Fluorescence In Situ Hybridization (FISH)

Chromosome Analysis

HOX Genes

Applying Genomic and Proteomic Microarray Technology in Drug Discovery

Molecular Biomethods Handbook

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Peroxisomes