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  • High Throughput Gene Screening

    Methods and Protocols

    Serier serie Springer Protocols
    This volume explores the latest advancements in the high-throughput sequencing (HTS) technologies and its uses in our understanding of complex biological processes and human diseases. The chapters in this book are organized into five parts and cover topics such as genome based-sequencing technologies, including whole genome sequencing, targeted sequencing, and metagenomic analysis; epigenome-based ... Læs mere

    1.414,11 kr.

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  • Bioinformatics and Functional Genomics

    The bestselling introduction to bioinformatics and genomics – now in its third editionWidely received in its previous editions, Bioinformatics and Functional Genomics offers the most broad-based introduction to this explosive new discipline. Now in a thoroughly updated and expanded third edition, it continues to be the go-to source for students and professionals involved in biomedical research ... Læs mere

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    Gene Transfer Technologies and Applications

    This book describes basic cell engineering methods, emphasizing stem cell applications, and use of the genetically modified stem cells in cell therapy and drug discovery. Together, the chapters introduce and offer insights on new techniques for engineering of stem cells and the delivery of transgenes into stem cells via various viral and non-viral systems. The book offers a guide to the types of ... Læs mere

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  • Drosophila

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    This third edition expands on the previous editions by providing updated protocols and current methods that cover recent breakthroughs in Drosophila research. Chapters guide readers through FlyBase, versatile gene expression systems, analysis of microRNA function, single-cell transcriptome data and metabolism, recent applications of CRISPR for precise genome editing, transcriptional activation and ... Læs mere

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  • Chromoanagenesis

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    This extensive volume explores the phenomena of chaotic genomic rearrangements, known as chromoanagenesis, their formation mechanisms, and the state-of-the-art techniques used to detect them. The book delves into the potential impact of chromoanagenesis on cancers and congenital diseases, as well as its broader implications for genomic evolution and human health through a variety of cutting-edge ... Læs mere

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  • Transcription Factor Regulatory Networks

    Redigeret af Qi Song, Zhipeng Tao ...
    Serier serie Springer Protocols
    This book covers various state-of-the-art techniques regarding the associations between transcription factors (TFs) and genes, with a focus on providing methodological and practical references for researchers. The contents cover diverse protocols and summaries of TFs including screening of TF-DNA interactions, detection of open chromatin regions, identification of epigenetic regulations, ... Læs mere

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  • HIV-1 Proteomics

    From Discovery to Clinical Application

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  • Cancer Cytogenetics and Cytogenomics

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  • Molecular Analyses

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    DNA and RNA extraction methods from a variety of tissues and samples are now routine, including extraction from single cells. Many methods are now automated. Sequencing efficiency has reached the point where it is now possible to obtain gigabases of data, both quickly and inexpensively. Such methods permit the identification of gene versions, including those associated with disease (e.g. small ... Læs mere

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    This detailed new edition broadens the scope of the first edition by moving beyond classical display technologies. This book explores methodologies for the generation of natively paired antibody libraries, single cell technologies, alternative scaffolds, and in silico antibody sequence assessments are described. The application of these methods may allow for a generation of improved therapeutics ... Læs mere

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  • Epigenome Editing

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    Redigeret af Albert Jeltsch, Marianne G. Rots ...
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    This second volume details new and updated methods covering applications of epigenome editing. Chapters guide readers through general and topical reviews, DNA-binding devices, optimization of the effector domains, readout of epigenome marks, and approaches for delivery at the cellular and organismal level. Written in the highly successful Methods in Molecular Biology series format, chapters ... Læs mere

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