Synthetic Analgesics provides a comprehensive discussion of morphinans and 6,7-benzomorphans. Morphinans belong to a class of compounds possessing the main structural skeleton of morphine. Chemists have attempted to modify the morphine molecule in order to obtain analgesics without side-effects and addictive properties. The book is organized into two parts. Part A discusses the chemistry and pharmacology of morphinans, covering the syntheses of analgesics with morphine-like activity, N-met...

The quick and easy way to master EKG procedures and use your knowledge in real-world situationsIf you're looking for a fun, fast review that boils EKGs down to the most essential, must-know points your search ends here! EKGs for Nursing Demystified is a thorough yet concise overview of this medical test, complete with time-proven techniques, facsimiles of EKG strips, and numerous clinical cases. You will learn how to interpret hypertrophy and enlargement, arrhythmias, co...

Pharmacovigilance Medical Writing covers the preparation of pharmacovigilance documents for all stages of the drug development process (i.e. from clinical development through to applications for marketing authorisations to the post-marketing stage). For each document, the book presents a review of the regulatory framework that governs the content of the document, followed by practical guidance (e.g. scheduling, source data, department/functions involved in document preparation/rev...

Clinical Pharmacology During Pregnancy is written for clinicians, physicians, midwives, nurses, pharmacists and other medical professionals directly involved in the care of women during pregnancy. This book focuses on the impact of pregnancy on drug disposition and also includes coverage of treatments for diseases of specific body systems as well as essential content on dosing and efficacy.The broad range of this book encompasses analgesics, antiasthmatics, antidepressants...

This work describes the importance of tumor microenvironment in favouring tumor progression and angiogenesis.Under physiological conditions, angiogenesis is dependent on the balance of positive and negative angiogenic modulators within the vascular microenvironment and requires the functional activities of a number of molecules, including angiogenic factors, extracellular matrix proteins, adhesion molecules and proteolytic enzymes.In normal tissues, vascular quiescence is m...

Aqueous-based film coating has become routine in the pharmaceutical industry. This process eliminates the use of organic solvents and thus avoids economic, environmental, and toxicological issues related to residual solvents and solvent recovery. Aqueous-based coating, however, is complex and many variables may impact the final product and its performance. This fourth edition of Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms aims to provide insight into the factors and...

Bipolar disorder, or manic depression, is characterised by episodes of pathological mood states. The two poles are mania (with a predominant elated or irritable mood) and depression (with feelings of sadness, anxiety, guilt or hopelessness) but mixed states frequently occur. Episodes can last for many months and profoundly affect physical health, relationships and careers. Since diagnosis and management are difficult, this practical guide provides an overview of the disorder and detailed g...

Specially designed computer software is revolutionizing procedures for structured or rational drug design and discovery. The Guidebook on Molecular Modeling in Drug Design serves as a manual for the analysis ofmolecular structure and the correlation of these structures with pharmacological reactions. Intended as an introductory guide for advanced students and professionals with an interest in computer-assisted modeling for drug design and discovery, this bookwill also be of interest to med...

An essential outline of the main facets of polypharmacology in drug discovery researchExtending drug discovery opportunities beyond the "one drug, one target" philosophy, a polypharmacological approach to the treatment of complex diseases is emerging as a hot topic in both industry and academic research. Polypharmacology in Drug Discovery presents an overview of the various facets of polypharmacology and how it can be applied as an innovative concept for developing medicines for tr...

Frontiers in Anti-Cancer Drug Discovery is an eBook series devoted to publishing the latest and the most important advances in Anti-Cancer drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The eBook series should prove to be of interest to a...

Rare Diseases and Orphan Drugs shows that much of what we now know about common diseases has been achieved by studying rare diseases. It proposes that future advances in the prevention, diagnosis, and treatment of common diseases will come as a consequence of our accelerating progress in the field of rare diseases. Understanding the complex steps in the development of common diseases, such as cancer, cardiovascular disease, and metabolic diseases, has proven a difficult problem. Rare disea...

Nicotine is the major factor in the continuation of the smoking habit among humans. On December 2-4, 1985, under the sponsorship of the Tobacco and Health Research Institute in Lexington, Kentucky, leading scientists from around the world whose research efforts have focused on the role of nicotine in the tobacco habit participated in an International Symposium to provide the most comprehensive and ~xtensive coverage of this topic so far. The material discussed was in the forefront of man's...